Lymphomatoid Papulosis - Lymphomatoid Papulosis Information

Lymphomatoid papulosis (LyP; Macaulay disease) is a chronic lymphoproliferative disease of the skin characterized by recurrent crops of pruritic papules that may ulcerate. Lymphomatoid papulosis often lasts for years. Patients need to see their doctor regularly to make sure their condition does not turn into cancer. This condition is slightly more common in women. Although most cases of lymphomatoid papulosis are benign, 10-20% of patients may have an associated lymphoma before, at the same time as, or after the diagnosis of lymphomatoid papulosis.

Causes of Lymphomatoid Papulosis

proliferation of atypical T-cell lymphocytes (funny-looking white cells).
In some people lymphomatoid papulosis turns into lymphoma which is a form of cancer. This happens in about one out of ten people.

Treatment of Lymphomatoid Papulosis

Lymphomatoid papulosis is difficult to treat and there is no cure for this condition. It often lasts for years, over which time patients need to regularly see their doctor to pick up any changes that may signal early lymphoma.Treatments of Lymphomatoid Papulosis which may be successful include:

Cortisone ointments will sometimes help.
Ultraviolet light treatment will help control lymphomatoid papulosis.
Methotrexate is sometimes used to treat lymphomatoid papulosis.

Low-dose weekly methotrexate is a safe and effective treatment for suppressing Lymphomatoid papulosis; however, the disease recurs within 1-2 weeks after ending medication.

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