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Erythema Multiforme Information
Erythema multiforme is an acute inflammatory skin disease. Erythema multiforme is divided clinically into minor and major types based on the clinical findings. Approximately 90% of cases of erythema multiforme minor follow outbreaks of herpes simplex.
Erythema multiforme may also present as recurring oral ulceration, with skin lesions present in only half of the cases, and is diagnosed by oral biopsy. Since erythema multiforme may have its own prodrome, many medications taken for such symptoms have been implicated in its pathogenesis without definitive proof. Erythema Multiforme major and minor Erythema multiforme major and minor (Stevens-Johnson syndrome) is marked by toxicity and involvement of two or more mucosal surfaces (often oral and conjunctival) and is most often caused by drugs, especially sulfonamides, nonsteroidal anti-inflammatory drugs, and anticonvulsants such as phenytoin . Mycoplasma pneumoniae may trigger erythema multiforme major. Symptom of Acne vulgaris
A classic target lesion, found most commonly in herpes-associated erythema multiforme, consists of three concentric zones of color change, most often found acrally on the hands and feet. Not all lesions will have this appearance. Drug-associated erythema multiforme is manifested by raised target-like lesions, with only two zones of color change and a central blister, or nondescript reddish or purpuric macules. In erythema multiforme major, mucous membrane ulcerations are present at two or more sites, causing pain on eating, swallowing, and urination.
Treatment of Acne vulgaris
Erythema multiforme major (Stevens-Johnson syndrome) with extensive denudation of skin is best treated in a burn unit. Otherwise, patients need not be admitted unless mucosal involvement interferes with hydration and nutrition. Patients who begin to blister should be seen daily. Immediate discontinuation of the inciting medication (before blistering occurs) improves prognosis and reduces the risk of death in erythema multiforme major.
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