Neurofibromatosis is a chronic skin disorder. Neurofibromatosis is a common condition which can occur in any age group. Neurofibromatosis is a neurocutaneous syndrome, it's passed down through the parents' genes, and it affects the brain, spinal cord, nerves, and skin. Neurofibromatosis is a neurocutaneous condition that can involve almost any organ system. Thus, the presenting signs and symptoms may vary widely.