Bowen's disease (intraepidermal squamous cell carcinoma) occurs either on sun-exposed or sun-protected cutaneous surfaces. The lesion is usually a small (1–3 cm), well-demarcated, slightly raised, pink to red, scaly plaque and may resemble psoriasis or a large actinic keratosis. While it may take some time, these lesions may progress to invasive squamous cell carcinoma. Excision or other definitive treatment is indicated.
Sign and Symptom of Bowen's Disease
Symptoms may include itching, weakness, malaise, fever, and weight loss. Chills are prominent. Redness and scaling may be generalized and sometimes include loss of hair and nails. Generalized lymphadenopathy may be due to lymphoma or leukemia or may be part of the clinical picture of the skin disease (dermatopathic lymphadenitis). The mucosa is spared.